Sebastian Gensior

Alzheimer’s disease, the most common form of dementia, poses one of the greatest challenges in modern medicine. Every year, about 10 million people around the world are diagnosed with dementia, and over 55 million are currently living with it. As populations age, those numbers are projected to rise to

It begins, as all good policies do, with a peer-reviewed article. A study from 2013 estimates the cost of a hospital stay for rheumatoid arthritis. The figure is well-argued, methodologically neat, and printed in an impeccable journal. The number is then cited in a 2017 HTA submission. That

The first half of 2025 has seen a wave of new venture capital (VC) and private equity (PE) funds dedicated to pharmaceuticals and biotech, even as the broader funding climate remains cautious. Investors are selectively raising and deploying billions into life sciences – from mega-funds amassing war chests for drug

1. Introduction: The Gospel of the Target In the parlance of modern pharmaceuticals, few words carry the theological weight of "target." Scientists chant it, investors demand it, and regulators inquire after it with the reverence of high priests examining relics. If one believes the marketing, every drug these

I. Introduction: The Double-Edged Scalpel of AI in Drug Discovery The relentless pursuit of new medicines remains a cornerstone of human health, yet it is a quest characterized by exorbitant costs, protracted timelines, and a notoriously high failure rate.The traditional drug development pipeline, from initial discovery to market

The Return of the “Magic Bullet” In 1908, the German scientist Paul Ehrlich coined the term “Zauberkugel” – magic bullet – envisioning a drug that could target disease with pinpoint accuracy while sparing healthy tissue. Over a century later, antibody–drug conjugates (ADCs) aim to fulfill that vision. An ADC couples a

The Next Big Patent Cliff Looms Pharmaceutical investors are once again bracing for what industry insiders ominously dub a “patent cliff.” In 2027-2028 alone, drugs accounting for roughly $180 billion in annual sales – nearly 12% of the global pharma market – will lose patent protection. This wave includes some of

The first half of 2025 saw an unprecedented surge in royalty-based financings and structured revenue deals across the biopharmaceutical sector. Faced with a bleak equity market and tightening credit, drug developers from Boston to Basel turned to royalty monetization as a lifeline. In the span of January to June

Trials, Errors, and Timely Trades In the rarefied world of biotech, miracles in the lab often meet murkier practices in the market. Consider a small Massachusetts biotech last year: as it anxiously awaited a pivotal clinical trial readout, a curious flurry of phone calls and stock sales began emanating from

A Corporate Pastoral in Four Acts By one who has seen the lanyards and despaired. DRAMATIS PERSONAE * CLAIRE DU VAGUE — Moderator. Professional panelist wrangler. Speaks only in pre-approved key messages. * DR. BLAKE THERESE — Systems biologist turned consultant. Confident. Unclear. * LEONTYNE GRIMM — CEO of HelixBioTrust. Appears remotely. Transmits authority in