Latest

30
Jun
The Surrogate Marker Paradox in Chronic Disease

The Surrogate Marker Paradox in Chronic Disease

Why Many Interventions Improve a Biomarker Without Altering the Underlying Condition Surrogate Markers vs True Outcomes Clinical research often relies
13 min read
29
Jun
Certified to Death (With Distinction)

Certified to Death (With Distinction)

The modern pharmaceutical and scientific job market, dear reader, has developed a peculiar affliction—no, not another variant, but something
3 min read
28
Jun
Biotech’s Glass Cage: The Overton Window, the Asymmetric Risk Trap, and the Limits of Scientific Imagination

Biotech’s Glass Cage: The Overton Window, the Asymmetric Risk Trap, and the Limits of Scientific Imagination

It is not often that the bounds of acceptable discourse are described in terms of architecture. Yet the Overton Window—
5 min read
27
Jun
The Biotech Deck Drinking Game

The Biotech Deck Drinking Game

10 Slides You'll Always See If you've been pitched by more than three biotech startups in
3 min read
26
Jun
The Pivot Paradox

The Pivot Paradox

Why constant reinvention is both vital—and a sign you may have no idea what you're doing Once
3 min read
25
Jun
Global Pharma & Biotech M&A (Mar–Jun 2025): Deals, Drivers & Trends

Global Pharma & Biotech M&A (Mar–Jun 2025): Deals, Drivers & Trends

The second quarter of 2025 saw a surge in mergers and acquisitions (M&A) within the pharmaceutical and biotechnology
35 min read
24
Jun
From Tricorders to Tribbles: When Sci-Fi Becomes a Patent Filing

From Tricorders to Tribbles: When Sci-Fi Becomes a Patent Filing

It is a truth almost universally acknowledged—except, perhaps, in FDA review meetings—that no credible scientist gets funded anymore
5 min read
23
Jun
The shape of cures to come: AlphaFold’s structural revolution in drug discovery

The shape of cures to come: AlphaFold’s structural revolution in drug discovery

The decades-long puzzle of protein folding In the pantheon of scientific challenges, few have loomed as large or as stubborn
18 min read
22
Jun
No Cure Without Coverage: Digital Health’s Reimbursement Riddle

No Cure Without Coverage: Digital Health’s Reimbursement Riddle

When a small Berlin startup launched an obesity therapy app a few years ago, investors hailed it as a potential
23 min read
21
Jun
Real-World Data (RWD): The Messy Yet Essential Future of Healthcare

Real-World Data (RWD): The Messy Yet Essential Future of Healthcare

Real-World Data (RWD) is the equivalent of field notes in anthropology: messy, unstructured, but full of valuable insights about how
3 min read