Lonely at the Top: On the Myth and Misery of Being CEO
To outsiders, the CEO title glows with a sort of untouchable glamour. Power. Prestige. The final say. To founders, it’
Fundraising Folklore: Myths, Missteps, and Magical Thinking in Biotech
Biotech, more than most sectors, runs not just on capital—but on belief. And where belief goes, myths follow. Wrapped
Consensus Kills: Why You Should Pitch the One Thing No One Wants to Hear (Yet)
One of the oddest things about biotech investing is how often everyone agrees. We agree on the hot areas. We
The Fallacy of the One Big Exit: Why Building a Biotech Career Is Not a Lottery
The myth of the one big exit is a seductive one. It is the fairytale biotech tells itself over and
The Untapped Potential (and Perils) of Patient Advocacy in Drug Development
Patient advocacy. It sounds noble, doesn’t it? Empowering individuals to shape the medicines they desperately need, bringing the human
What Biotech Can Learn from Insurance: Actuarial Thinking in Drug Development
Biotech and insurance rarely appear in the same sentence unless one is covering the other. One traffics in breakthroughs and
The Maintenance Phase: What Nobody Tells You About Surviving Between Breakthroughs
There is a moment in every biotech startup’s lifecycle where the champagne has been corked, the deck has been
The Discount Rate Is a Lie: Risk Isn’t a Constant in Biotech
There is a quiet confidence with which financial analysts deploy the discount rate—that tidy little variable in a discounted
Comfort Is a Liability: Why You Should Stay Paranoid (Just a Little)
There’s a certain temptation, once things start working, to exhale. The team is humming. The product is shipping. The
What to Do in a Down Market (Besides Complain About It)
Every founder eventually learns the same lesson: the market does not care about your milestones. It doesn’t care that
