There’s a curious delusion that haunts modern professionals. The belief that before you start something—anything, really—you must first understand it completely. As if mastery precedes curiosity. As if competence is a prerequisite, not a result. It’s nonsense, of course. And nowhere is this more obvious than

What Is a p-Value? The p-value measures the probability of observing data as extreme as the actual results, assuming the null hypothesis (H0 ) is true. It does not measure the probability of the null hypothesis itself. Formally, the p-value is defined as: $$ p = P(\text{Data} \mid

There’s a specific look founders get when I ask, “What’s your runway?” It’s part shame, part bravado, and part magical thinking. “Maybe a couple of months,” they say, casually, like they’re describing a parking ticket. Sometimes, the answer is worse: “We already ran out, actually.” In

There you are—armed with a lukewarm flute of prosecco, trying to make small talk with a stem cell biologist in a conference centre that sounds like Heathrow Terminal 5 during a baggage handler strike. You lean in. You nod. You squint as though comprehension is a muscle group you’

There’s a peculiar optimism embedded in the English language: pulling yourself up by your bootstraps. The phrase is now Silicon Valley gospel—synonymous with grit, frugality, and making something from nothing. Originally, though, it was a joke. A 19th-century absurdity. The physical act of lifting oneself by one’

In Germany, there is a saying: "Wenn du Visionen hast, geh zum Arzt.” If you have visions, see a doctor. A punchline, yes, but also a worldview—orderly, sober, engineered for reliability. It's a good attitude for bridge-building or train schedules. But it’s a death

In the courtship rituals of modern fundraising, there exists a peculiar form of digital simping: the obsessive fawning over “curated investor lists.” Like suitors armed with a Rolodex of names but no real intimacy, startups fire off pitches to anyone vaguely associated with a term sheet. It’s Tinder for

Dan Davies—veteran analyst, ex-regulator, and professional myth-buster—has written what might be the most depressingly accurate book of 2024: The Unaccountability Machine: Why Big Systems Make Terrible Decisions—and How the World Lost Its Mind. It is, to put it politely, a masterclass in how large institutions

In drug development, most narratives hinge on averages—median survival times, mean biomarker expression, or standard response rates. Yet, breakthroughs often emerge from outliers, the rare patients who exhibit extraordinary therapeutic benefits. These individuals, known as super-responders, defy conventional expectations, revealing critical insights about a treatment’s potential and

In startups, we talk a lot about vision. Less about volume. But execution—unglamorous, cumulative, occasionally boring—is what actually moves the needle. You don’t build momentum with a big idea. You build it by showing up. So this year, I set a target: 365 posts in 365 days.